Modifying Enzymes
Cayman Chemical Oleoyl-L-carnItInchlorIde 25mg
A long-chain acylcarnitine and GlyT2 inhibitor (IC50 = 340 nM); selective for GlyT2 over GlyT1 (IC50 = >10,000 nM); plasma levels are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality
ABclonal Technology DNA Ligase I Rabbit mAb
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
Medchemexpress LLC Ribonuclease T1, Aspergillus oryzae | 9026-12-4 | 11.2 kDa monomer | 10 KU
Ribonuclease T1, Aspergillus oryzae | 9026-12-4 | 11.2 kDa monomer | 10 KU
Carnabio Usa Inc PIM2/10UG/FULL-LENGTH
PIM2, Full-length, Wild type, Amino Acid 1-311, NP_006866.2, Expressed in Insect (sf21); 10microg
Carnabio Usa Inc STLK3(STK39)/10UG/FULL-LENGTH
STLK3(STK39), Full-length, Wild type, Amino Acid 1-545, NP_037365.2, Expressed in Insect (sf21); 10microg
ABclonal Technology T4 RNA Ligase 2, truncated
T4 RNA Ligase 2, truncated (T4 Rnl2 truncated) specifically ligates the pre-adenylated 5 end of DNA or RNA to the 3 end of RNA. The enzyme does not require ATP for ligation but does need the pre-adenylated substrate. T4 Rnl2 truncated is expressed from a plasmid in E. coli which encodes the first 249 amino acids of the full length T4 RNA Ligase 2. Unlike the full length ligase, T4 Rnl2 truncated is unable to adenylate the 5 end of the substrate, and as a result it cannot ligate the phosphorylated 5? end of RNA or DNA to the 3? end of RNA. This enzyme, also known as Rnl2 (1-250) has been used for optimized linker ligation for the cloning of microRNAs. This enzyme reduces background ligation because it can only use adenylated primers.
Cayman Chemical Oleoyl-D-lysInsodIum salt 1mg
An inhibitor of GlyT2a; selectively inhibits GlyT2a (IC50 = 48.3 nM) over GlyT1b (IC50 = >3,000 nM) in Xenopus oocytes expressing the human transporters; reduces allodynia in a nerve ligation rat model of neuropathic pain at 30 mg/kg, i.p.
Biotium CD45 / LCA (Leucocyte Marker)(Bra55), CF568 conjugate, 0.1mg/mL
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
Selleck Chemical LLC Cabozantinib (BMS-907351) 200mg 849217-68-1 XL184
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3?/NF-?B signaling pathway. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
ABclonal Technology Mth RNA Ligase
Mth RNA Ligase is an ATP-dependent ligase that can efficiently convert 5-phosphorylated single-stranded DNA into 5-adenylated DNA. The kit has been optimized to yield high quantities of adenylylated DNA regardless of whether the 3 end of the single-stranded DNA has been aminated or otherwise modified. Typically, the modification efficiency can reach over 95%.
Cayman Chemical ACtylCoA Carboxylase 1 Rabb
A cGAS inhibitor (IC50 0.11 UM) inhibits dsDNA-induced IFN-B1-dependent gene expression in a reporter assay reduces basal Ifnb1 mRNA expression in BMDMs generated from the Trex1-/- mouse model of Aicardi-Goutières syndrome
Bio IVT CYP3A7 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
CYP3A7 Reductase Bactosomes, Human rCYP Enzyme, 1 nmol/vial
Crescent Chemical Co Inc GLUCOSE OXIDASE FROM A. NIGER
Glucose oxidase from Aspergillus niger min. 220 U/mg lyophil. Glucose oxidase is used in the assay of D-glucose (1). Ca. 300 U/mg protein. Size - 500MG Storage Conditions - -15 °C TO -25 °C Catalog Number - 22778.02 CAS 9001-37-0
Meridian Life Science P. falciparum MSP-1, Recomb.
Plasmodium falciparum (Malaria) merozoite surface protein 1 (MSP-1) Recombinant